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Synaptic consolidation is achieved faster than systems consolidation, within only minutes to hours of learning in goldfish.
LTP, one of the best understood forms of synaptic plasticity, is thought to be a possible underlying process in synaptic consolidation.
The two proposed the perseveration-consolidation hypothesis after they found that new information learned could disrupt information previously learnt if not enough time had passed to allow the old information to be consolidated.
Systematic studies of anterograde amnesia started to emerge in the 1960s and 1970s.
The standard model of synaptic consolidation suggests that alterations of synaptic protein synthesis and changes in membrane potential are achieved through activating intracellular transduction cascades.
These molecular cascades trigger transcription factors that lead to changes in gene expression.
The result of the gene expression is the lasting alteration of synaptic proteins, as well as synaptic remodeling and growth.
In a short time-frame immediately following learning, the molecular cascade, expression and process of both transcription factors and immediate early genes, are susceptible to disruptions.
M., became a landmark in studies of memory as it relates to amnesia and the removal of the hippocampal zone and sparked massive interest in the study of brain lesions and their effect on memory.When interpreted in the context of synaptic consolidation, mechanisms of synaptic strengthening may depend on the spacing of memory reactivation to allow sufficient time for protein synthesis to occur, and thereby strengthen long-term memory.Protein synthesis plays an important role in the formation of new memories.Long-term memory, when discussed in the context of synaptic consolidation, is memory that lasts for at least 24 hours.An exception to this 24-hour rule is long-term potentiation, or LTP, a model of synaptic plasticity related to learning, in which an hour is thought to be sufficient.